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Rabbit Anti-XBP-1
Catalog Number :HZ642462 Quantity size : 0.1ml （dilute with pH 7.4
0.01 M PBS or antibody diluent ）
Background: This gene encodes a transcription factor that regulates MHC class
II genes by binding to a promoter element referred to as an X box. This gene product
is a bZIP protein, which was also identified as a cellular transcription factor that binds
to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may
increase expression of viral proteins by acting as the DNA binding partner of a viral
transactivator. It has been found that upon accumulation of unfolded proteins in the
endoplasmic reticulum （ER）, the mRNA of this gene is processed to an active form by
an unconventional splicing mechanism that is mediated by the endonuclease
inositol-requiring enzyme 1 （IRE1）. The resulting loss of 26 nt from the spliced mRNA
causes a frame-shift and an isoform XBP1（S）, which is the functionally active
transcription factor. The isoform encoded by the unspliced mRNA, XBP1（U）, is
constitutively expressed, and thought to function as a negative feedback regulator of
XBP1（S）, which shuts off transcription of target genes during the recovery phase of
ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
[provided by RefSeq].
Subcellular Location : Nucleus.
Similarity : Belongs to the bZIP family.
Contains 1 bZIP domain.
Involvement in disease;Genetic variations in XBP1 could be associated with
susceptibility to major affective disorder type 7 （MAFD7）. Major affective disorders
represent a class of mental disorders characterized by a disturbance in mood as their
predominant feature.
specificity :
– Anti- XBP-1 is a rabbit polyclonal antibody unconjugated
– specific for XBP-1 of human, mouse and rat
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 29kDa
Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– ELISA 1:500-1000
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The
lyophilized antibody is stable at room temperature for at least one month and for
greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M
PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Important Note: This product as supplied is intended for research use only, not for
use in human, therapeutic or diagnostic applications.